Research projects
  • Cardiovascular diseases and associated comorbidities:
    • PI: Patricio Soares-da-Silva (5 members)
      • To evaluate the role of oxidative stress, inflammation and activation of intrarenal dopaminergic and renin-angiotensin-aldosterone systems in the pathophysiology of cardiovascular diseases and associated comorbidities. Special emphasis is given to renal mechanisms involved in sodium handling and blood pressure regulation.
    • PI: Pedro Gomes (2 members)
      • To test the hypothesis that activation of NAD-dependent protein deacetylase sirtuin 2 (SIRT2) could improve insulin sensitivity in experimental models of insulin resistance, by normalizing oxidative stress levels, a key feature of this condition.
    • PI: Teresa Sousa (6 members)
      • To evaluate the role of hydrogen peroxide as a regulator of the renin-angiotensin system (RAS) and blood pressure in experimental models of hypertension.
      • To investigate the interaction of low-dose acetylsalicylic acid (ASA) with antihypertensive drugs and its impact on renal oxidative stress, inflammation, local renin-angiotensin system activation and blood pressure control in experimental models of hypertension.
      • To evaluate the role of anti-inflammatory eicosanoids (lipoxins) and oxidative stress in the pathophysiology of human heart failure – therapeutic implications.
  • Molecular mechanisms involved in diabetic erectile dysfunction:
    • PI: Carla Costa (2 members)
      • Our group has been devoted to the study of molecular mechanisms associated to diabetic erectile dysfunction, namely angiogenic alterations and oxidative stress.
  • Obesity and adipose tissue metabolism and morphology:
    • PI: Conceição Calhau (8 members)
      • To examine dietary phenolic compounds impact on metabolism.
      • To examine the involvement of persistent organic pollutants, in particular those with estrogenic activity (xenoestrogens), on metabolic dysfunction.
  • Diet-induced metabolic syndrome (through fructose ingestion) modulation by minerals (through the ingestion of a Portuguese natural mineral-rich water) Diet-induced obesity (through high-fat diet ingestion) modulation by exercise:
    • PI: Maria João Martins (4 members)
  • Transporte transmembranar de compostos bioativos:
    • PI: Fátima Martel (12 members)
      • Characterization of cell membrane transport of bioactive compounds at intestinal epithelial level, placental level and cancer cells and its modulation by endogenous and exogenous compounds and in some human pathologies.
  • Angiogenesis and inflammation team:
    • PI: Raquel Soares (8 members)
      • To examine the angiogenic paradox in diabetes.
      • To investigate the association with chronic inflammation, oxidative stress and lymphangiogenesis.
      • Role of polyphenols as angiogenesis and inflammation modulators.
      • To examine the role of vascular wall cells in tissue regeneration.


Centre of Pharmacology and Chemical Biopathology

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