- Cardiovascular diseases and associated comorbidities:
- PI: Patricio Soares-da-Silva (5 members)
evaluate the role of oxidative stress, inflammation and activation of
intrarenal dopaminergic and renin-angiotensin-aldosterone systems in
the pathophysiology of cardiovascular diseases and associated
comorbidities. Special emphasis is given to renal mechanisms involved
in sodium handling and blood pressure regulation.
- PI: Pedro Gomes (2 members)
test the hypothesis that activation of NAD-dependent protein
deacetylase sirtuin 2 (SIRT2) could improve insulin sensitivity in
experimental models of insulin resistance, by normalizing oxidative
stress levels, a key feature of this condition.
- PI: Teresa Sousa (6 members)
evaluate the role of hydrogen peroxide as a regulator of the
renin-angiotensin system (RAS) and blood pressure in experimental
models of hypertension.
- To investigate the
interaction of low-dose acetylsalicylic acid (ASA) with
antihypertensive drugs and its impact on renal oxidative stress,
inflammation, local renin-angiotensin system activation and blood
pressure control in experimental models of hypertension.
evaluate the role of anti-inflammatory eicosanoids (lipoxins) and
oxidative stress in the pathophysiology of human heart failure –
- Molecular mechanisms involved in diabetic erectile dysfunction:
- PI: Carla Costa (2 members)
group has been devoted to the study of molecular mechanisms associated
to diabetic erectile dysfunction, namely angiogenic alterations and
- Obesity and adipose tissue metabolism and morphology:
- PI: Conceição Calhau (8 members)
- To examine dietary phenolic compounds impact on metabolism.
examine the involvement of persistent organic pollutants, in particular
those with estrogenic activity (xenoestrogens), on metabolic
- Diet-induced metabolic syndrome (through
fructose ingestion) modulation by minerals (through the ingestion of a
Portuguese natural mineral-rich water) Diet-induced obesity (through
high-fat diet ingestion) modulation by exercise:
- PI: Maria João Martins (4 members)
- Transporte transmembranar de compostos bioativos:
- PI: Fátima Martel (12 members)
of cell membrane transport of bioactive compounds at intestinal
epithelial level, placental level and cancer cells and its modulation
by endogenous and exogenous compounds and in some human pathologies.
- Angiogenesis and inflammation team:
- PI: Raquel Soares (8 members)
- To examine the angiogenic paradox in diabetes.
- To investigate the association with chronic inflammation, oxidative stress and lymphangiogenesis.
- Role of polyphenols as angiogenesis and inflammation modulators.
- To examine the role of vascular wall cells in tissue regeneration.
Centre of Pharmacology and